Dimerix adds second drug to development suite

Published at Jul 29, 2016, in ASX Biotechs

Dimerix (ASX:DXB) has added a second development program to the deck, with DMX-250 targeting fibrosis in patients with non-alcoholic steatohepatits – and it’s already had promising results.

DXB told its shareholders yesterday that in addition to the DMX-200 program under development to help sufferers of chronic kidney disease, that it was now investigating using a combination of angiotensin receptor blockers and propagermanium.

This combination was discovered using DXB’s proprietary screening assay, termed Receptor-Heteromer Investigation Technology (Receptor-HIT) – the same method used to identify DMX-200 and formed the basis of an internal drug development program, initially for the treatment of a subset of patients with chronic kidney disease.

DMX-250 will be developed with an eye towards curing non-alcoholic steatohepatitis, which carries the risk of progression into liver fibrosis and ultimately hepatocellular carcinoma – or liver cancer.

There is no established treatment for the disease, and it’s estimated that 6 million people are suffering from it in the US alone.

According to DXB, DMX-250 has had a positive effect while being used in a mouse model – warranting further investigation.

Investors should note that this is a very early stage drug and there is no guarantee of success – investors are advised to seek out the advice of a professional before investing.

In any case, the new drug adds a second drug onto the development schedule for DXB to augment its work in DMX-200.

It added that it was in the process of developing further pre-clinical studies for DMX-250.

About DXB and DMX 200

DXB has been hard at work progressing the DMX-200 drug through clinical trials in Melbourne.

The aim is to demonstrate that DMX-200 can safely reduce the level of proteinuria in the body.

Proteinuria is the presence of abnormal levels of protein in urine, which can be an indicator of chronic kidney disease in a patient.

Reducing proteinuria lowers the chances of CKD progression and its consequences such as the loss of renal function, and the development and progression of cardiovascular disease.

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