Cortisol inhibition – a potential new approach to treating Alzheimer’s disease

Published at Jun 29, 2016, in ASX Biotechs

Data on a potential breakthrough treatment for Alzheimer’s disease (AD), based on excess cortisol regulation in the human brain, will be presented at the Alzheimer’s Association International Conference (AAIC), held in Toronto, Canada in July.

The company behind the novel, cortisol-focused approach is Actinogen Medical (ASX:ACW), an ASX-listed biotech company that’s just recently entered Stage 2 clinical trials evaluating Xanamem as a promising new treatment for mild Alzheimer’s disease.

The invitation for ACW to present its findings and ongoing research at AAIC, is a first step for ACW to publicise its research on Xanamem, alongside the growing understanding of the serious impact of excess cortisol on the human brain

ACW will present a talk titled, “XanamemTM a novel 11β–HSD1 inhibitor with potential to provide durable symptomatic and disease modifying benefits in Alzheimer’s disease”. The presentation is expected to include the latest results on XanamemTM, ACW’s flagship pharmaceutical product that could prove to be a significant new treatment for Alzheimer’s disease.

One of the first major hurdles in proving the efficacy of Xanamem, was confirming the drug’s ability to cross the blood-brain barrier. ACW successfully achieved this milestone and has now launched an in-depth Phase 2 drug trial in mild Alzheimer’s disease, called XanADu.

A further important study being presented at AAIC, will present data supporting ACW’s overarching hypothesis on the adverse effects of cortisol on the human brain. Data from a landmark study undertaken by the independent AIBL Research Group in Australia, demonstrates the clear association between excess cortisol and the development of Alzheimer’s disease.

The AIBL study is funded by various Australian government agencies and universities, including the CSIRO, and strongly endorses the cortisol hypothesis that underlies the development of XanamemTM as a treatment option for Alzheimer’s disease.

ACW will begin an extensive series of presentations and data publications over the coming 6 months, advancing its “cortisol hypothesis” and publicising its work. More publicity could potentially serve as price catalysts for ACW, currently priced at $0.075 per share and valued at A$46 million by market capitalisation.

Dr. Bill Ketelbey, CEO of Actinogen Medical.

“We eagerly anticipate these trials being presented to the worldwide medical and scientific community, at such a prestigious forum. This will be the first broad-based exposure of these results, in advance of their publication later this year. This exciting new data on Xanamem, alongside the strongly supportive AIBL results linking excess cortisol with Alzheimer’s disease, provides powerful independent endorsement for Actinogen’s development of XanamemTM in Alzheimer’s disease,” said Dr. Bill Ketelbey, CEO of Actinogen Medical.

Where to invest $1,000 right now

When the experts at Next Investors have a stock pick, it may pay to listen.

The Next Investors have been investing in ASX small cap stocks for years, with their best small cap picks yielding returns of 1,200%, 1,120%, 900% and 678%.

They have just revealed their hand-picked, FY2021 stock portfolio of high conviction long-term investments.

Click the link below to see what they are currently investing in.


S3 Consortium Pty Ltd (CAR No.433913) is a corporate authorised representative of LeMessurier Securities Pty Ltd (AFSL No. 296877). The information contained in this article is general information only. Any advice is general advice only. Neither your personal objectives, financial situation nor needs have been taken into consideration. Accordingly you should consider how appropriate the advice (if any) is to those objectives, financial situation and needs, before acting on the advice.

Conflict of Interest Notice

S3 Consortium Pty Ltd does and seeks to do business with companies featured in its articles. As a result, investors should be aware that the Firm may have a conflict of interest that could affect the objectivity of this article. Investors should consider this article as only a single factor in making any investment decision. The publishers of this article also wish to disclose that they may hold this stock in their portfolios and that any decision to purchase this stock should be done so after the purchaser has made their own inquires as to the validity of any information in this article.

Publishers Notice

The information contained in this article is current at the finalised date. The information contained in this article is based on sources reasonably considered to be reliable by S3 Consortium Pty Ltd, and available in the public domain. No “insider information” is ever sourced, disclosed or used by S3 Consortium.

Australian ASX Small Cap stocks | Why is Australia’s leading small cap publication

Founded seven years ago, is Australia’s leading and longest standing website for investor and finance news, education and expert opinion.

Published by StocksDigital, Finfeed was created to report daily on the comings and goings of ASX listed stocks in the small cap market.

As the first digital publication dedicated specifically to this space, Finfeed soon became the most trusted publication in the market, quickly garnering over two million page views – a number that continues to rise. provides its readers with informative articles that tackle the latest in market moving #ASX small cap news, plus exclusive content you won’t find anywhere else. It is aimed at those with an interest in investing, market education, company performance, start-ups and much more. is the only media organisation operating under the strength of a Financial Services License and is backed by leading journalists and analysts all with brands of their own.

The website aims to inform, educate and entertain with content that drills down into the heart of financial matters.

Finfeed is a leading source of investor and market information, with everything investors need to know about how to invest written in a way that anyone can understand. 

Over the years, the website has expanded beyond exclusively reporting on small caps, to profile Australia’s leading ASX listed small, mid and large caps as well as some of the country’s most successful CEOs and business leaders to find out what makes them tick.

Every day you will find fresh content covering:

Fast Facts

Over 4,000 articles published

Over 2.3 Million Page Views and counting

Over 10,000 followers on social media

Subscriber list growing by 2% monthly

Thanks for subscribing!